Argonne’s High-throughput Research Laboratory (HTRL) in the Chemical Sciences and Engineering Division provides highly-automated and parallel approaches to materials development. This unique capability allows scientists to synthesize and screen large numbers of compounds, by covering a wide range of compositional space and optimize their reaction conditions much more rapidly, more efficiently and in more reproducible way than can be done by conventional approaches, thereby reducing the time and cost. The large and organized data set generated are well-suited for supporting machine learning efforts. The mission of the HTRL is to be able to address the challenges posed by the diverse projects ranging from basic to applied science, in the fields of catalysis, solar conversion, fuel cells, and energy storage. Specifically, the HTRL aims at accelerating material and process discovery to address current and future energy demands and environmental issues with emphasis on a circular economy.